\n
VANCOUVER, British Columbia, 06. Okt. 2020 (GLOBE NEWSWIRE) \u2013 Derm-Biome Pharmaceuticals, Inc, ein privates biopharmazeutisches Unternehmen mit Sitz in Vancouver, das sich auf Hautgesundheit und gesundes Altern konzentriert, freut sich bekannt zu geben, dass eines seiner topischen Medikamente erhebliche Ergebnisse erbracht hat dosisabh\u00e4ngige Hemmwirkungen in einem gut etablierten Mausmodell f\u00fcr Psoriasis. Psoriasis ist eine chronisch entz\u00fcndliche Hauterkrankung, die oft mit Depressionen und einer verminderten Lebensqualit\u00e4t einhergeht. Der weltweite Markt f\u00fcr Psoriasis-Behandlungen soll bis 2026 ein Volumen von $37 Milliarden US-Dollar erreichen. Diese Ergebnisse folgen auf eine erfolgreiche pr\u00e4klinische Studie bei atopischer Dermatitis Anfang dieses Jahres mit demselben Medikament.<\/p>\n
Im Versuch konnten wir in allen getesteten Konzentrationsbereichen signifikante, dosisabh\u00e4ngige Hemmwirkungen beobachten. Das als Positivkontrolle eingesetzte Psoriasis-Medikament Tapinarof von Dermavant Sciences zeigte in einer pr\u00e4klinischen Studie mit demselben Mausmodell ebenfalls eine signifikante antipsoriatische Aktivit\u00e4t. Unser Medikament zeigte in einem \u00e4hnlichen Konzentrationsbereich vergleichbare hemmende Wirkungen wie Tapinarof. Der Wirkstoff von Derm-Biome hemmt die Produktion entz\u00fcndungsf\u00f6rdernder Zytokine, reguliert entz\u00fcndungshemmende Mediatoren einschlie\u00dflich Interferonen und anderen entz\u00fcndungshemmenden Zytokinen hoch und steigert die Expression von Proteinen, die f\u00fcr die Aufrechterhaltung einer wirksamen Hautbarriere von entscheidender Bedeutung sind. Die Verbindung f\u00f6rdert auch die Diversit\u00e4t des Hautmikrobioms, indem sie das Wachstum pathogener Bakterien, einschlie\u00dflich Staphylokokken und C. Aknes, hemmt.<\/p>\n
Dr. Youwen Zhou, Professor in der Abteilung f\u00fcr Dermatologie und Hautwissenschaften der University of British Columbia: \u201eMeine Gruppe hat sowohl die Psoriasis- als auch die atopische Dermatitis-Studien f\u00fcr Derm-Biome mit bew\u00e4hrten Mausmodellen durchgef\u00fchrt, die meiner Meinung nach diese menschlichen Krankheiten genau nachahmen.\u201c Ich habe diese Mausmodelle auch f\u00fcr andere Pr\u00fcfpr\u00e4parate und von der FDA zugelassene Medikamente verwendet. Der Derm-Biome-Wirkstoff blockierte dosisabh\u00e4ngig die Entwicklung von Psoriasis und atopischer Dermatitis, sowohl im Hinblick auf die Entz\u00fcndungswerte als auch auf die Hemmung der Entz\u00fcndungsmediatoren dieser Erkrankungen. Es handelt sich um einen Wirkstoff mit vielversprechendem Potenzial f\u00fcr die Behandlung dieser Krankheiten.\u201c<\/p>\n
Gordon Eberwein, CEO von Derm-Biome: \u201eWir sind mit den Ergebnissen dieser Studie sehr zufrieden. Unser topisches Medikament greift Zytokine an, die nicht nur bei Psoriasis \u00fcberexprimiert werden, sondern auch bei unterversorgten Subtypen der atopischen Dermatitis, darunter asiatischer, p\u00e4diatrischer und nichtallergischer Art, eine wichtige Rolle spielen. Aktuelle Medikamente zielen haupts\u00e4chlich nur auf die Th2-Aktivierung ab, was dazu f\u00fchrt, dass weniger als die H\u00e4lfte der erwachsenen Neurodermitis-Patienten Verbesserungen versp\u00fcren. Wir sind definitiv der Meinung, dass hier eine enorme Chance liegt.\u201c<\/p>\n
Derm-Biome hat sich an Health Canada gewandt und um Hilfe bei der Beantragung einer klinischen Studie (Clinical Trial Application, CTA) gebeten. Eine pr\u00e4klinische Studie zu Akne wird voraussichtlich noch in diesem Jahr beginnen.<\/p>\n
Um <\/strong>Derm<\/strong>-Biome Pharmaceuticals, Inc<\/strong><\/p>\nDerm-Biome Pharmaceuticals, Inc. ist ein privates pr\u00e4klinisches biopharmazeutisches Unternehmen mit \u00fcber 40 nat\u00fcrlichen Derivaten, Salzen und Co-Kristallen, das sich der Verbesserung der Hautgesundheit und eines gesunden Alterns widmet. Unsere Verbindungen sind gut vertr\u00e4glich und weisen neuartige entz\u00fcndungshemmende, antimikrobielle und antioxidative Eigenschaften auf.<\/p>\n
Kontakt<\/strong>
\nInvestorenanfragen:
\nGordon Eberwein
\ngeberwein@derm-biome.com<\/a>
\nhttps:\/\/derm-biomepharmaceuticals.com\/<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n[\/vc_column_text][\/vc_column][\/vc_row]<\/p>","protected":false},"excerpt":{"rendered":"
[vc_row css_animation=”” row_type=”row” use_row_as_full_screen_section=”no” type=”full_width” angled_section=”no” text_align=”left” background_image_as_pattern=”without_pattern”][vc_column][vc_column_text] VANCOUVER, British Columbia, Oct. 06, 2020 (GLOBE NEWSWIRE) — Derm-Biome Pharmaceuticals, Inc, a private Vancouver based biopharmaceutical company focused on skin health and healthy ageing, is pleased to announce that one of its topical drugs produced significant, and dose dependent inhibitory effects in a well established mouse […]<\/p>","protected":false},"author":2,"featured_media":349,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[5],"tags":[],"class_list":["post-351","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recent-news"],"yoast_head":"\n
Derm-Biome Pharmaceuticals, Inc. Reports Positive Results from a Preclinical Study In Psoriasis - Derm-Biome Pharmaceuticals Inc.<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/derm-biomepharmaceuticals.com\/de_de_formal\/derm-biome-pharmaceuticals-inc-reports-positive-results-from-a-preclinical-study-in-psoriasis\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Derm-Biome Pharmaceuticals, Inc. 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